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Agilent Technologies Introduces Focused Exome Kit with Unparalleled Coverage, Speed, Flexibility for Disease Research

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Agilent Technologies Inc. (NYSE:A) today introduced the SureSelect Focused Exome, a target enrichment solution that enables deep coverage of only those target regions that have been associated with disease. The latest design is 16 Mb in size and enables 98 percent of targeted regions to be covered with 20 or more reads with only 3 Gb of sequencing, allowing for sensitive detection of variants within a given sample.

The SureSelect Focused Exome enables clinical researchers to confidently make variant calls in regions of significance by targeting regions defined in HGMD, OMIM and ClinVar databases. The efficient design is a benchtop-sequencing-compatible solution for unbiased detection of variants relevant in the pathogenesis of rare disorders.

The highly optimized design, 3.5 times smaller than the full exome, enables greater flexibility in sample throughput, providing a cost-effective means of analyzing disease-associated targets. Custom content can also be added to the Focused Exome using SureDesign, allowing for a capture design to be tailored to meet the specific needs of the clinical researcher. The SureSelect Focused Exome can be paired with existing SureSelect target enrichment protocols with greatly reduced hybridization times, as little as 90 minutes, to provide sequencing-ready libraries in one day. This complete target-enrichment workflow solution enables faster time to definitive answers and accelerates discoveries in constitutional disease research.

“The SureSelect Focused Exome completes Agilent’s constitutional disease portfolio and meets the specialized needs of all types of clinical researchers,” said Alessandro Borsatti, senior director of Marketing for Agilent’s Diagnostics and Genomics group. “Whether they are studying rare disorders that necessitate comprehensive interrogation of the exome, disease-related regions, or Mendelian disorders with known etiology that only require analysis of very specific targets, researchers now have an ideal solution compatible with any type of exome sequencing platform.”

Agilent’s SureSelect portfolio is the industry’s leading target enrichment solution. The Focused Exome is the latest addition to the exome sequencing family, which includes the SureSelect Clinical Research Exome and SureSelectQXT. Combined, these solutions provide clinical researchers the higher coverage of disease-associated regions with the fastest hybridization-based target enrichment workflow needed to enable faster time to answers. SureSelect provides a complete solution for researchers to quickly and easily analyze specific regions of the genome, transcriptome and methylome. As part of the complete solution, SureSelect is supported by SureDesign software that enables custom capability, Bravo automation platforms that enable reproducibility and high-throughput sample processing, and SureCall software that enables quick, easy, streamlined analysis of genomic regions of interest.

Click here to learn more about the SureSelect Focused Exome.

About Agilent Technologies

Agilent Technologies Inc. (NYSE:A) is a leader in chemical analysis, life sciences, diagnostics, electronics and communications. The company’s 20,600 employees serve customers in more than 100 countries. Agilent had revenues of $6.8 billion in fiscal 2013. Information about Agilent is available at

In September 2013, Agilent announced plans to separate into two publicly traded companies through a tax-free spinoff of its electronic measurement business. On Aug. 1, 2014, the company’s electronic measurement business began operating as Keysight Technologies, Inc., a wholly owned subsidiary. The separation is expected to be completed in early November 2014.

Forward-Looking Statements

This news release contains forward-looking statements as defined in the Securities Exchange Act of 1934 and is subject to the safe harbors created therein. The forward-looking statements contained herein include, but are not limited to, information regarding the separation of Agilent’s electronic measurement business; future revenues, earnings and profitability; the future demand for the company’s products and services; and customer expectations. These forward-looking statements involve risks and uncertainties that could cause Agilent’s results to differ materially from management’s current expectations. Such risks and uncertainties include, but are not limited to, unforeseen changes in the strength of our customers’ businesses; unforeseen changes in the demand for current and new products, technologies, and services; customer purchasing decisions and timing, and the risk that we are not able to realize the savings expected from integration and restructuring activities.

In addition, other risks that Agilent faces include those detailed in Agilent’s filings with the Securities and Exchange Commission, including our latest Form 10-K and Form 10-Q. Forward-looking statements are based on the beliefs and assumptions of Agilent’s management and on currently available information. Agilent undertakes no responsibility to publicly update or revise any forward-looking statement.

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