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Epizyme to Report First Quarter 2015 Financial Results and Provide Corporate Update on April 28, 2015

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Epizyme, Inc. (NASDAQ:EPZM) , a clinical stage biopharmaceutical company creating novel epigenetic therapies for cancer patients, announced today that it will host a conference call and live audio webcast on Tuesday, April 28, 2015, at 4:30 PM ET to report first quarter 2015 financial results and provide a corporate update.

To participate in the conference call, please dial 1-877-844-6886 (domestic) or 1-970-315-0315 (international) and refer to conference ID 32270626. The live webcast can be accessed under “Events and Presentations” in the Investor Relations section of the Company’s website at www.epizyme.com.

About Epizyme, Inc.

Epizyme, Inc. is a clinical stage biopharmaceutical company creating novel epigenetic therapeutics for cancer patients. Epizyme has built a proprietary product platform that the Company uses to create small molecule inhibitors of a 96-member class of enzymes known as histone methyltransferases, or HMTs. HMTs are part of the system of gene regulation, referred to as epigenetics, that controls gene expression. Genetic alterations can result in changes to the activity of HMTs, making them oncogenic (cancer-causing). By focusing on the genetic drivers of cancers, Epizyme’s targeted science seeks to match the right medicines with the right patients.

For more information, visit www.epizyme.com and connect with us on Twitter at @EpizymeRx.

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